Enantioselective total synthesis of (+)-salvileucalin B.
نویسندگان
چکیده
An enantioselective total synthesis of the diterpenoid natural product (+)-salvileucalin B is reported. Key findings include a copper-catalyzed arene cyclopropanation reaction to provide the unusual norcaradiene core and a reversible retro-Claisen rearrangement of a highly functionalized norcaradiene intermediate.
منابع مشابه
Rapid assembly of the salvileucalin B norcaradiene core.
Preparation of the polycyclic core of the cytotoxic natural product salvileucalin B is described. The key feature of this synthetic strategy is a copper-catalyzed intramolecular arene cyclopropanation to provide the central norcaradiene. These studies lay the foundation for continued investigations toward an enantioselective total synthesis of 1.
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ورودعنوان ژورنال:
- Journal of the American Chemical Society
دوره 133 4 شماره
صفحات -
تاریخ انتشار 2011